李刚

研究方向：心血管疾病的转化医学研究

邮箱： ligang@xmu.edu.cn；gangli1982@outlook.com。

电话：15860726189

教育背景：

2001.09-2005.06 西北大学   生物科学    本科

2007.09-2010.06 厦门大学  心血管药理学  硕士

2013.09-2017.06 厦门大学  心血管生理学  博士

工作经历：

2010.07-至今  厦门大学附属心血管病医院                 研究实习员/助理研究员/副研究员

2013.09-2015.03 香港大学李嘉诚医学院                   访问学者

主要研究领域：

长期从事心血管疾病的转化医学研究，主要关注基因或新型药物对血管新生、动脉粥样硬化、心梗、心肌肥厚、高血压、主动脉夹层、血管或心肌衰老等心血管疾病的作用和机制研究。

研究成果：

以第一/通讯作者在国际知名杂志发表SCI文章26篇，其中中科院一区6篇，影响因子大于10分4篇；主持国家自然科学基金面上项目2项、省市级科研项目6项，以主要参与人完成1项国家自然基金联合基金重点项目；研究成果获福建省科技进步二等奖一项（2024年度，第三完成人），厦门市科技进步奖二等奖一项（2021年度，第三完成人）、三等奖两项（2014年度）。

主持国家和省市级项目：

1. 国家自然科学基金面上项目，IGFBP5通过E3泛素连接酶ITCH调控BCL2泛素化对内皮和动脉粥样硬化的作用和机制研究（82470474），执行时间：2025.1-2028.12，项目负责人。

2. 国家自然科学基金面上项目，IGFBP5调节FGF16-m6A甲基化修饰调控血管新生的功能和机制研究（82270417），执行时间：2023.1-2026.12，项目负责人。

3. 福建省自然科学基金项目，胰岛素样生长因子受体结合蛋白5通过自噬通路对心梗的作用和调控机制研究（2023J011677），执行时间：2023.8.1-2026.8.1，项目负责人。

4. 福建省卫生健康科技项目，piRNA-1910在病理性心肌肥厚中的作用及机制研究（2024CXB018），执行时间2025.01-2027.06，项目负责人。

5. 厦门市医疗卫生重点项目，新型非编码小RNA-piRNA调控病理性心肌肥厚的作用和机制研究（3502Z20244010），执行时间: 2025.01-2027.12，项目负责人。

6. 厦门市科技局科技惠民项目，缓激肽调控心脏祖细胞的外泌体对血管生成的作用及机制研究（350Z20184025），执行时间：2018.12-2021.12，项目负责人。

7. 厦门市科技局科技惠民项目，MicroRNA对阿托伐他汀在抑制内皮细胞炎症的调节研究（350Z20134042），执行时间：2012.11-2015.11，项目负责人。

8. 福建省卫生厅青年基金项目，IL-18天然拮抗剂IL-18结合蛋白抗动脉粥样硬化的作用研究(2013-2-87)， 执行时间：2012.8-2015.8，项目负责人。

第一或通讯文章（*通讯）:

[1] Ruiying Wang, Ruo-Lan Chen, Chan Wu, Xiao-Cheng Zhang, Wei-Yin Wu, Cuilian Dai, Yan Wang*, Gang Li*. The gut microbiotas with metabolites regulate the protective role of miR-30a-5p in myocardial infarction. J Adv Res. 2024 Oct 21:S2090-1232(24)00472-7. doi: 10.1016/j.jare.2024.10.017.

[2] Yi-Xiang Hong, Chan Wu, Jing-Zhou Li, Fei Song, Yu Hu, Yue Han, Yi-Jie Mao, Wei-Yin Wu, Yan Wang*, Gang Li*. SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence. Exp Mol Med. 2024 Nov 7. doi: 10.1038/s12276-024-01347-3.

[3] Fei Song, Yu Hu, Yi-Xiang Hong, Hu Sun, Yue Han, Yi-Jie Mao, Wei-Yin Wu, Gang Li*, Yan Wang*. Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis. Clin Transl Med. 2024 Jun;14(6):e1725. doi: 10.1002/ctm2.1725.

[4] Ruiying Wang, Xiaocheng Zhang, Yutian Wang, Yijun Lin, Yuling Zhou, Yan Wang*, Gang Li*. Gut microbiota of miR-30a-5p-deleted mice aggravate high-fat diet-induced hepatic steatosis by regulating arachidonic acid metabolic pathway. Clin Transl Med. 2024 Oct;14(10):e70035. doi: 10.1002/ctm2.70035.

[5] Chan Wu, Xiao-Cheng Zhang, Lan-Ruo Chen, Hui-Zhu Huang, Wei-Yin Wu, Yan Wang*, Gang Li*. Pyroptosis and mitochondrial function participated in miR-654-3p-protected against myocardial infarction. Cell Death Dis. 2024 Jun 4;15(6):393. doi: 10.1038/s41419-024-06786-4.

[6] Chan Wu, Yi-Xiang Hong, Xiao-Cheng Zhang, Jing-Zhou Li, Yu-Ting Li, Jun Xie, Rui-Ying Wang, Yan Wang*, Gang Li*. SIRT1-dependent regulation of mitochondrial metabolism participates in miR-30a-5p-mediated cardiac remodeling post-myocardial infarction. Free Radic Biol Med. 2024 Nov 16:226:117-128.

[7] Wei-Min Han, Yi-Xiang Hong, Guo-Sheng Xiao, Rui-Ying Wang, Gang Li*. NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis. Cell Death Discov. 2024 Jan 17;10(1):34. doi: 10.1038/s41420-023-01794-3.

[8] Binghong Liu, Fei Song, Xiaoxia Zhou, Chan Wu, Huizhu Huang, Weiyin Wu, Gang Li*, Yan Wang*. NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells J Cell Mol Med. 2024 Apr;28(8):1-11. doi: 10.1111/jcmm.18233.

[9] Wei-Min Han, Xiao-Bin Hao, Yi-Xiang Hong, Shan-Shan Zhao, Xu-Chang Chen, Ruiying Wang, Yan Wang*, Gang Li*. NMDARs Antagonist MK801 Suppresses LPS-induced Apoptosis and Mitochondrial Dysfunction by Regulating Subunits of NMDARs via the CaM/CaMKII/ERK Pathway. Cell Death Discovery. 2023 Feb 11;9(1):59. doi: 10.1038/s41420-023-01362-9.

[10] Song F, Lin J, Zhang H, Guo Y, Mao Y, Liu Z, Li G*, Wang Y*. Long-Term Sleep Deprivation-Induced Myocardial Remodeling and Mitochondrial Dysfunction in Mice Were Attenuated by Lipoic Acid and N-Acetylcysteine. Pharmaceuticals (Basel). 2022 Dec 29;16(1):51. doi: 10.3390/ph16010051. PMID: 36678548; PMCID: PMC9866495.

[11] Zheng Jinrong, Qi Ruiqiang, Dai Cuilian, Li Gang*, Sang Mangmang*. Enzyme Catalysis Biomotor Engineering of Neutrophils for Nanodrug Delivery and Cell-Based Thrombolytic Therapy. ACS Nano. 2022 Feb 22;16(2):2330-2344. doi: 10.1021/acsnano.1c08538. Epub 2022 Feb 9.

[12] Zheng Jinrong, Zhao Shanshan, Mao Yijie, Du Z, Li Gang*, Sang Mangmang*. Lipid-Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch. Small. 2022 Feb;18(5):e2104471. doi: 10.1002/smll.202104471. Epub 2021 Nov 27. 

[13] Song Fei#, Li Jing-Zhou#, Wu Yao#, Wu Wei-Yin, Wang Yan*, Li Gang*. Ubiquitinated ligation protein NEDD4L participates in MiR-30a-5p attenuated atherosclerosis by regulating macrophage polarization and lipid metabolism. Mol Ther Nucleic Acids. 2021 Nov 4; 26: 1303-1317. doi: 10.1016/j.omtn.2021.10.030. eCollection 2021 Dec 3. 

[14] Yan Pianpian, Wu Xijie, Cai Feifei, Chen Yi, Huang Yiqing, Li Gang*, Keke Lai*. Efficacy and safety of sugammadex in anesthesia of cardiac surgery: A retrospective study. J Clin Anesth. 2020 Oct;65:109845. doi: 10.1016/j.jclinane.2020.109845. Epub 2020 May 26.

[15] Wu Chan, Zhou Xiao-Xia, Li Jing-Zhou, Qiang Hai-Feng, Wang Yan*, Li Gang*. Pretreatment of cardiac progenitor cells with bradykinin attenuates H2O2-induced cell apoptosis and improves cardiac function in rats by regulating autophagy. Stem Cell Res Ther. 2021 Aug 5;12(1):437. doi: 10.1186/s13287-021-02503-6.

[16] Wu Chan, Liu Binghong, Wang Ruiying*, Li Gang*. The Regulation Mechanisms and Clinical Application of MicroRNAs in Myocardial Infarction: A Review of the Recent 5 Years. Front Cardiovasc Med. 2021;8: 809580. 

[17] Wu Yao, Song Fei, Li Yun-Da, Li Jing-Zhou, Cui Yu-Kai, Hong Yi-Xiang, Li Gang*, Wang Yan*. Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE(-/-) Mice. J Cell Mol Med. 2021;25: 521-34.

[18] Li Gang, Che Hui, Wu WeiYin, Jie Ling-Jun, Xiao Guo-Sheng, Wang Yan*, Gui-Rong Li*. Bradykinin-mediated Ca (2+) signalling regulates cell growth and mobility in human cardiac c-Kit (+) progenitor cells. J Cell Mol Med. 2018;22: 4688-99.

[19] Fei Song#, Yi-Jie Mao#, Yu Hu, Shan-Shan Zhao, Ruiying Wang, Wei-Yin Wu, Yan Wang* and Gang Li*. Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via the PPARa/AMPK pathway. European Journal of Pharmacology. 2022. May 5;922:174916. doi: 10.1016/j.ejphar.2022.174916. Epub 2022 Mar 24. 

[20] Song Ying, Song Fei, Wu Chan, Hong Yi-Xiang, Li Gang*. The roles of epicardial adipose tissue in heart failure. Heart Fail Rev. 2022;27: 369-77.

[21] Song Fei, Zhou Xiao-Xia, Hu Yu, Li Gang*, Wang Yan*. The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases. Adv Ther. 2021;38: 885-903. 

[22] Chan Wu#, Ruo-Lan Chen#, Yan Wang, Wei-Yin Wu*, Gang Li*. Acacetin alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and apoptosis via the Nrf-2/HO-1 pathway. Pharm Biol. 2022; Dec;60(1):553-561. doi: 10.1080/13880209.2022.2041675.

[23] Li Jing-Zhou#, Zhou Xiao-Xia#, Wu Wei-Yin, Qiang Hai-Feng, Xiao Guo-Sheng, Wang Yan*, Li Gang*. Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis. Pharm Biol. 2022; 60:65-74.

[24] Li Gang*, Song Ying, Li Yun-Da, Jie Ling-Jun, Wu Wei-Yin, Li JZ, Wang Y*. Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure. Biomark Med. 2018;12: 871-80.

[25] Li Gang, Wang Yan*, Li Gui-Rong*. Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells. Oncotarget. 2017;8: 10822-35.

[26] Xiao-Cheng Zhang, Chan Wu, Yun-Da Li, Jing-Zhou Li, Wei-Yin Wu, Le Zhang, Ruiying Wang, Gang Li*. miR-30a-5p preserves cardiac homeostasis by reprogramming metabolic checkpoints in hypertrophic cardiomyopathy. Life Sci. 2025 Dec 16:386:124154. doi: 10.1016/j.lfs.2025.124154. Online ahead of print.